Increasingly, US and international policy makers have requested our Group's assistance in developing analyses of HIV/AIDS issues of particular concern to them. Here are a few examples of such activities.

• In 2001, the United States Office of Minority Health asked us to conduct a series of systematic reviews of interventions addressing HIV prevention among minority populations in the United States. The findings were disseminated to health departments and community-based organizations for use in program development.
• In 2002, the World Health Organization (WHO) asked us to prepare a series of 7 systematic reviews of antiretroviral drugs in combination therapy for treating HIV/AIDS, outlining which drugs should be used in combination therapy. WHO added the drugs to the "WHO Model List of Essential Medicines."
• In late 2003, we were asked by the Milbank Memorial Fund and the Council on Foreign Relations to prepare an assessment of the evidence supporting various intervention strategies for HIV/AIDS prevention, treatment and care, with a particular focus on resource-constrained settings. The assessment was used for testimony to high-level State Department personnel in preparation for the Institute of Medicine’s consensus committee report titled “Scaling Up Treatment for the Global AIDS Pandemic: Challenges and Opportunities.”
• Working with the State of California Department of Health Services (DHS), in conjunction with the California HIV/AIDS Research Program (CHRP), we prepared systematic reviews of behavioral prevention in heterosexual African-Americans, and another for prevention in men who have sex with men (MSM) of color. This was for inclusion in CHRP's "California Collaborations in HIV Prevention Research Dissemination Project." In 2008, we completed another systematic review for this series, this time on behavioral prevention interventions for women of color in the United States.
• In early 2006, WHO asked us to review the evidence for essential care and prevention interventions for people living with HIV/AIDS. With colleagues from WHO and the Johns Hopkins University, Bloomberg School of Public Health, we developed the evidence to inform new WHO guidelines for these interventions.
• With the International Planned Parenthood Federation (IPPF), the United Nations Population Fund (UNFPA), the World Health Organization, and the Johns Hopkins University, Bloomberg School of Public Health, we conducted a systematic review of the evidence for linkages between sexual and reproductive health and HIV services.
• In 2009, we worked closely with to WHO in developing the evidence for a range of new Guidelines. This work comprised eleven systematic reviews (along with more than 50 GRADE evidence profiles) relevant to children with HIV infection; adult and adolecescent antiretroviral therapy; and prevention of mother-to-child HIV infection.
• Over the course of two months in 2010, we prepared three systematic reviews (with accompanying GRADE profiles) of "novel strategies" for preventing HIV infection in men who have sex with men (MSM) and transgender women. Incorporating this evidence, WHO released new guidelines on preventing HIV in MSM and transgender persons in June, 2011.
• For WHO in 2011, we prepared six reviews (with many GRADE profiles) to inform new guidelines on cryptococcal infection in adults and children with HIV. The "Rapid Advice" document for these guidelines was released on 7 December 2011. The full guidelines will be released in 2012.
• For WHO, two reviews to inform new guidelines on HIV prevention in sero-discordant couples

In 2012:

• To inform new consolidated WHO guidelines (for release in 2013), 12 reviews on antiretroviral therapy and on prevention of mother to child transmission; nine reviews on treatment optimization and health services delivery for people with HIV; and four reviews relevant to optimizing treatment and care of adolescents with HIV.
• Also for WHO guidelines, three reviews on micronutrient supplementation for children with HIV, for pregnant women with HIV, and for non-pregnant adults with HIV.